Autophagy Protects Monocytes from Wolbachia Heat Shock Protein 60–Induced Apoptosis and Senescence
Identifieur interne : 002101 ( Main/Exploration ); précédent : 002100; suivant : 002102Autophagy Protects Monocytes from Wolbachia Heat Shock Protein 60–Induced Apoptosis and Senescence
Auteurs : Vijayan Kamalakannan [Inde] ; Abijit Shiny [Inde] ; Subash Babu [Inde] ; Rangarajan Badri Narayanan [Inde]Source :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2015.
Abstract
Monocyte dysfunction by filarial antigens has been a major mechanism underlying immune evasion following hyporesponsiveness during patent lymphatic filariasis. Recent studies have initiated a paradigm shift to comprehend the immunological interactions of
Url:
DOI: 10.1371/journal.pntd.0003675
PubMed: 25849993
PubMed Central: 4388636
Affiliations:
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India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialties Centre, Chennai, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>National Institutes of Health—National Institute for Research in Tuberculosis-International Center for Excellence in Research, National Institute for Research in Tuberculosis, Chetpet, Chennai, Tamil Nadu, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>National Institutes of Health—National Institute for Research in Tuberculosis-International Center for Excellence in Research, National Institute for Research in Tuberculosis, Chetpet, Chennai, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil 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sort="Kamalakannan, Vijayan" uniqKey="Kamalakannan V" first="Vijayan" last="Kamalakannan">Vijayan Kamalakannan</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Centre for Biotechnology, Anna University, Chennai, Tamil Nadu, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Centre for Biotechnology, Anna University, Chennai, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Shiny, Abijit" sort="Shiny, Abijit" uniqKey="Shiny A" first="Abijit" last="Shiny">Abijit Shiny</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialties Centre, Chennai, Tamil Nadu, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialties Centre, Chennai, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>National Institutes of Health—National Institute for Research in Tuberculosis-International Center for Excellence in Research, National Institute for Research in Tuberculosis, Chetpet, Chennai, Tamil Nadu, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>National Institutes of Health—National Institute for Research in Tuberculosis-International Center for Excellence in Research, National Institute for Research in Tuberculosis, Chetpet, Chennai, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Narayanan, Rangarajan Badri" sort="Narayanan, Rangarajan Badri" uniqKey="Narayanan R" first="Rangarajan Badri" last="Narayanan">Rangarajan Badri Narayanan</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Centre for Biotechnology, Anna University, Chennai, Tamil Nadu, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Centre for Biotechnology, Anna University, Chennai, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS Neglected Tropical Diseases</title><idno type="ISSN">1935-2727</idno><idno type="eISSN">1935-2735</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Monocyte dysfunction by filarial antigens has been a major mechanism underlying immune evasion following hyporesponsiveness during patent lymphatic filariasis. Recent studies have initiated a paradigm shift to comprehend the immunological interactions of <italic>Wolbachia</italic> and its antigens in inflammation, apoptosis, lymphocyte anergy, etc. Here we showed that recombinant <italic>Wolbachia</italic> heat shock protein 60 (rWmhsp60) interacts with TLR-4 and induces apoptosis in monocytes of endemic normal but not in chronic patients. Higher levels of reactive oxygen species (ROS) induced after TLR-4 stimulation resulted in loss of mitochondrial membrane potential and caspase cascade activation, which are the plausible reason for apoptosis. Furthermore, release in ROS owing to TLR-4 signaling resulted in the activation of NF-κB p65 nuclear translocation which leads to inflammation and apoptosis via TNF receptor pathway following the increase in IL-6 and TNF-α level. Here for the first time, we report that in addition to apoptosis, rWmhsp60 antigen in filarial pathogenesis also induces molecular senescence in monocytes. Targeting TLR-4, therefore, presents a promising candidate for treating rWmhsp60-induced apoptosis and senescence. Strikingly, induction of autophagy by rapamycin detains TLR-4 in late endosomes and subverts TLR-4-rWmhsp60 interaction, thus protecting TLR-4–mediated apoptosis and senescence. Furthermore, rapamycin-induced monocytes were unresponsive to rWmhsp60, and activated lymphocytes following PHA stimulation. This study demonstrates that autophagy mediates the degradation of TLR-4 signaling and protects monocytes from rWmhsp60 induced apoptosis and senescence.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sahoo, Mk" uniqKey="Sahoo M">MK Sahoo</name></author><author><name sortKey="Sisodia, Bs" uniqKey="Sisodia B">BS Sisodia</name></author><author><name sortKey="Dixit, S" uniqKey="Dixit S">S Dixit</name></author><author><name sortKey="Joseph, Sk" uniqKey="Joseph S">SK Joseph</name></author><author><name sortKey="Gaur, Rl" uniqKey="Gaur R">RL Gaur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krishna, Kumari A" uniqKey="Krishna K">Kumari A Krishna</name></author><author><name sortKey="Harichandrakumar, Kt" uniqKey="Harichandrakumar K">KT Harichandrakumar</name></author><author><name sortKey="Das, Lk" uniqKey="Das L">LK Das</name></author><author><name sortKey="Krishnamoorthy, K" uniqKey="Krishnamoorthy K">K Krishnamoorthy</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Maizels, Rm" uniqKey="Maizels R">RM Maizels</name></author><author><name sortKey="Yazdanbakhsh, M" uniqKey="Yazdanbakhsh M">M Yazdanbakhsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="P G, Loke Asm" uniqKey="P G L">Loke ASM P’ng</name></author><author><name sortKey="Robb, A" uniqKey="Robb A">A Robb</name></author><author><name sortKey="Maizels, Rm" uniqKey="Maizels R">RM Maizels</name></author><author><name sortKey="Allen, Je" uniqKey="Allen J">JE Allen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Semnani, Rt" uniqKey="Semnani R">RT Semnani</name></author><author><name sortKey="Liu, Ay" uniqKey="Liu A">AY Liu</name></author><author><name sortKey="Sabzevari, H" uniqKey="Sabzevari H">H Sabzevari</name></author><author><name sortKey="Kubofcik, J" uniqKey="Kubofcik J">J Kubofcik</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Semnani, Rt" uniqKey="Semnani R">RT Semnani</name></author><author><name sortKey="Sabzevari, H" uniqKey="Sabzevari H">H Sabzevari</name></author><author><name sortKey="Iyer, R" uniqKey="Iyer R">R Iyer</name></author><author><name sortKey="Nutman, Tb" uniqKey="Nutman T">TB Nutman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Semnani, Rt" uniqKey="Semnani R">RT Semnani</name></author><author><name sortKey="Keiser, Pb" uniqKey="Keiser P">PB Keiser</name></author><author><name sortKey="Coulibaly, Yi" uniqKey="Coulibaly Y">YI Coulibaly</name></author><author><name sortKey="Keita, F" uniqKey="Keita F">F Keita</name></author><author><name sortKey="Diallo, Aa" uniqKey="Diallo A">AA Diallo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamalakannan, V" uniqKey="Kamalakannan V">V Kamalakannan</name></author><author><name sortKey="Kirthika, S" uniqKey="Kirthika S">S Kirthika</name></author><author><name sortKey="Haripriya, K" uniqKey="Haripriya K">K Haripriya</name></author><author><name sortKey="Babu, S" uniqKey="Babu S">S Babu</name></author><author><name sortKey="Narayanan, Rb" uniqKey="Narayanan R">RB Narayanan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sasisekhar, B" uniqKey="Sasisekhar B">B Sasisekhar</name></author><author><name sortKey="Aparna, M" uniqKey="Aparna M">M Aparna</name></author><author><name sortKey="Augustin, Dj" uniqKey="Augustin D">DJ Augustin</name></author><author><name sortKey="Kaliraj, P" uniqKey="Kaliraj P">P Kaliraj</name></author><author><name sortKey="Kar, Sk" uniqKey="Kar S">SK Kar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Md" uniqKey="Taylor M">MD Taylor</name></author><author><name sortKey="Legoff, L" uniqKey="Legoff L">L LeGoff</name></author><author><name sortKey="Harris, A" uniqKey="Harris A">A Harris</name></author><author><name sortKey="Malone, E" uniqKey="Malone E">E Malone</name></author><author><name sortKey="Allen, Je" uniqKey="Allen J">JE Allen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cross, Hf" uniqKey="Cross H">HF Cross</name></author><author><name sortKey="Haarbrink, M" uniqKey="Haarbrink M">M Haarbrink</name></author><author><name sortKey="Egerton, G" uniqKey="Egerton G">G Egerton</name></author><author><name sortKey="Yazdanbakhsh, M" uniqKey="Yazdanbakhsh M">M Yazdanbakhsh</name></author><author><name sortKey="Taylor, Mj" uniqKey="Taylor M">MJ Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dreyer, G" uniqKey="Dreyer G">G Dreyer</name></author><author><name sortKey="Noroes, J" uniqKey="Noroes J">J Noroes</name></author><author><name sortKey="Figueredo Silva, J" uniqKey="Figueredo Silva J">J Figueredo-Silva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saint Andre, Av" uniqKey="Saint Andre A">AV Saint Andre</name></author><author><name sortKey="Blackwell, Nm" uniqKey="Blackwell N">NM Blackwell</name></author><author><name sortKey="Hall, Lr" uniqKey="Hall L">LR Hall</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author><author><name sortKey="Brattig, Nw" uniqKey="Brattig N">NW Brattig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaufmann, Sh" uniqKey="Kaufmann S">SH Kaufmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaufmann, Sh" uniqKey="Kaufmann S">SH Kaufmann</name></author><author><name sortKey="Schoel, B" uniqKey="Schoel B">B Schoel</name></author><author><name sortKey="Embden, Jdav" uniqKey="Embden J">JDAV Embden</name></author><author><name sortKey="Koga, T" uniqKey="Koga T">T Koga</name></author><author><name sortKey="Wand Wurttenberger, A" uniqKey="Wand Wurttenberger A">A Wand-Wurttenberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Retzlaff, C" uniqKey="Retzlaff C">C Retzlaff</name></author><author><name sortKey="Yamamoto, Y" uniqKey="Yamamoto Y">Y Yamamoto</name></author><author><name sortKey="Hoffman, Ps" uniqKey="Hoffman P">PS Hoffman</name></author><author><name sortKey="Friedman, H" uniqKey="Friedman H">H Friedman</name></author><author><name sortKey="Klein, Tw" uniqKey="Klein T">TW Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mayr, M" uniqKey="Mayr M">M Mayr</name></author><author><name sortKey="Metzler, B" uniqKey="Metzler B">B Metzler</name></author><author><name sortKey="Kiechl, S" uniqKey="Kiechl S">S Kiechl</name></author><author><name sortKey="Willeit, J" uniqKey="Willeit J">J Willeit</name></author><author><name sortKey="Schett, G" uniqKey="Schett G">G Schett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stewart, Gr" uniqKey="Stewart G">GR Stewart</name></author><author><name sortKey="Young, Db" uniqKey="Young D">DB Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van, Ew" uniqKey="Van E">EW Van</name></author><author><name sortKey="Van Der Zee, R" uniqKey="Van Der Zee R">R Van der Zee</name></author><author><name sortKey="Prakken, B" uniqKey="Prakken B">B Prakken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suba, N" uniqKey="Suba N">N Suba</name></author><author><name sortKey="Shiny, C" uniqKey="Shiny C">C Shiny</name></author><author><name sortKey="Taylor, Mj" uniqKey="Taylor M">MJ Taylor</name></author><author><name sortKey="Narayanan, Rb" uniqKey="Narayanan R">RB Narayanan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shiny, C" uniqKey="Shiny C">C Shiny</name></author><author><name sortKey="Krushna, Ns" uniqKey="Krushna N">NS Krushna</name></author><author><name sortKey="Babu, S" uniqKey="Babu S">S Babu</name></author><author><name sortKey="Elango, S" uniqKey="Elango S">S Elango</name></author><author><name sortKey="Manokaran, G" uniqKey="Manokaran G">G Manokaran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brattig, Nw" uniqKey="Brattig N">NW Brattig</name></author><author><name sortKey="Bazzocchi, C" uniqKey="Bazzocchi C">C Bazzocchi</name></author><author><name sortKey="Kirschning, Cj" uniqKey="Kirschning C">CJ Kirschning</name></author><author><name sortKey="Reiling, N" uniqKey="Reiling N">N Reiling</name></author><author><name sortKey="Buttner, Dw" uniqKey="Buttner D">DW Buttner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kol, A" uniqKey="Kol A">A Kol</name></author><author><name sortKey="Bourcier, T" uniqKey="Bourcier T">T Bourcier</name></author><author><name sortKey="Lichtman, Ah" uniqKey="Lichtman A">AH Lichtman</name></author><author><name sortKey="Libby, P" uniqKey="Libby P">P Libby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author><author><name sortKey="Syldath, U" uniqKey="Syldath U">U Syldath</name></author><author><name sortKey="Bellmann, K" uniqKey="Bellmann K">K Bellmann</name></author><author><name sortKey="Burkart, V" uniqKey="Burkart V">V Burkart</name></author><author><name sortKey="Kolb, H" uniqKey="Kolb H">H Kolb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Da Costa, Cup" uniqKey="Da Costa C">CUP da Costa</name></author><author><name sortKey="Wantia, N" uniqKey="Wantia N">N Wantia</name></author><author><name sortKey="Kirschning, Cj" uniqKey="Kirschning C">CJ Kirschning</name></author><author><name sortKey="Busch, Dh" uniqKey="Busch D">DH Busch</name></author><author><name sortKey="Rodriguez, N" uniqKey="Rodriguez N">N Rodriguez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chanteau, S" uniqKey="Chanteau S">S Chanteau</name></author><author><name sortKey="Moulia Pelat, Jp" uniqKey="Moulia Pelat J">JP Moulia-Pelat</name></author><author><name sortKey="Glaziou, P" uniqKey="Glaziou P">P Glaziou</name></author><author><name sortKey="Nguyen, Nl" uniqKey="Nguyen N">NL Nguyen</name></author><author><name sortKey="Luquiaud, P" uniqKey="Luquiaud P">P Luquiaud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name></author><author><name sortKey="Balakrishnan, A" uniqKey="Balakrishnan A">A Balakrishnan</name></author><author><name sortKey="Miyamoto, S" uniqKey="Miyamoto S">S Miyamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dimri, Gp" uniqKey="Dimri G">GP Dimri</name></author><author><name sortKey="Lee, X" uniqKey="Lee X">X Lee</name></author><author><name sortKey="Basile, G" uniqKey="Basile G">G Basile</name></author><author><name sortKey="Acosta, M" uniqKey="Acosta M">M Acosta</name></author><author><name sortKey="Scott, G" uniqKey="Scott G">G Scott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brattig, Nw" uniqKey="Brattig N">NW Brattig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vabulas, Rm" uniqKey="Vabulas R">RM Vabulas</name></author><author><name sortKey="Ahmad Nejad, P" uniqKey="Ahmad Nejad P">P Ahmad-Nejad</name></author><author><name sortKey="Da Costa, C" uniqKey="Da Costa C">C da Costa</name></author><author><name sortKey="Miethke, T" uniqKey="Miethke T">T Miethke</name></author><author><name sortKey="Kirschning, Cj" uniqKey="Kirschning C">CJ Kirschning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Babu, S" uniqKey="Babu S">S Babu</name></author><author><name sortKey="Blauvelt, Cp" uniqKey="Blauvelt C">CP Blauvelt</name></author><author><name sortKey="Kumaraswami, V" uniqKey="Kumaraswami V">V Kumaraswami</name></author><author><name sortKey="Nutman, Tb" uniqKey="Nutman T">TB Nutman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zarember, Ka" uniqKey="Zarember K">KA Zarember</name></author><author><name sortKey="Godowski, Pj" uniqKey="Godowski P">PJ Godowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ganley Leal, Lm" uniqKey="Ganley Leal L">LM Ganley-Leal</name></author><author><name sortKey="Liang, Y" uniqKey="Liang Y">Y Liang</name></author><author><name sortKey="Jagannathan Bogdan, M" uniqKey="Jagannathan Bogdan M">M Jagannathan-Bogdan</name></author><author><name sortKey="Farraye, Fa" uniqKey="Farraye F">FA Farraye</name></author><author><name sortKey="Nikolajczyk, Bs" uniqKey="Nikolajczyk B">BS Nikolajczyk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Das, Ma" uniqKey="Das M">MA Das</name></author><author><name sortKey="Panda, Sk" uniqKey="Panda S">SK Panda</name></author><author><name sortKey="Pradhan, Ak" uniqKey="Pradhan A">AK Pradhan</name></author><author><name sortKey="Prusty, Bk" uniqKey="Prusty B">BK Prusty</name></author><author><name sortKey="Satapathy, Ak" uniqKey="Satapathy A">AK Satapathy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schumacker, Pt" uniqKey="Schumacker P">PT Schumacker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="West, Ap" uniqKey="West A">AP West</name></author><author><name sortKey="Brodsky, Ie" uniqKey="Brodsky I">IE Brodsky</name></author><author><name sortKey="Rahner, C" uniqKey="Rahner C">C Rahner</name></author><author><name sortKey="Woo, Dk" uniqKey="Woo D">DK Woo</name></author><author><name sortKey="Erdjument Bromage, H" uniqKey="Erdjument Bromage H">H Erdjument-Bromage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thornberry, Na" uniqKey="Thornberry N">NA Thornberry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, X" uniqKey="Yuan X">X Yuan</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Xie, G" uniqKey="Xie G">G Xie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mattson, Mp" uniqKey="Mattson M">MP Mattson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vicencio, Jm" uniqKey="Vicencio J">JM Vicencio</name></author><author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L Galluzzi</name></author><author><name sortKey="Tajeddine, N" uniqKey="Tajeddine N">N Tajeddine</name></author><author><name sortKey="Ortiz, C" uniqKey="Ortiz C">C Ortiz</name></author><author><name sortKey="Criollo, A" uniqKey="Criollo A">A Criollo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campisi, J" uniqKey="Campisi J">J Campisi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moore, Ta" uniqKey="Moore T">TA Moore</name></author><author><name sortKey="Reynolds, Jc" uniqKey="Reynolds J">JC Reynolds</name></author><author><name sortKey="Kenney, Rt" uniqKey="Kenney R">RT Kenney</name></author><author><name sortKey="Johnston, W" uniqKey="Johnston W">W Johnston</name></author><author><name sortKey="Nutman, Tb" uniqKey="Nutman T">TB Nutman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jung, Ch" uniqKey="Jung C">CH Jung</name></author><author><name sortKey="Ro, Sh" uniqKey="Ro S">SH Ro</name></author><author><name sortKey="Cao, J" uniqKey="Cao J">J Cao</name></author><author><name sortKey="Otto, Nm" uniqKey="Otto N">NM Otto</name></author><author><name sortKey="Kim, Dh" uniqKey="Kim D">DH Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuo, Cc" uniqKey="Kuo C">CC Kuo</name></author><author><name sortKey="Lin, Wt" uniqKey="Lin W">WT Lin</name></author><author><name sortKey="Liang, Cm" uniqKey="Liang C">CM Liang</name></author><author><name sortKey="Liang, Sm" uniqKey="Liang S">SM Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lorne, E" uniqKey="Lorne E">E Lorne</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name></author><author><name sortKey="Zmijewski, Jw" uniqKey="Zmijewski J">JW Zmijewski</name></author><author><name sortKey="Liu, G" uniqKey="Liu G">G Liu</name></author><author><name sortKey="Park, Yj" uniqKey="Park Y">YJ Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Puneet, P" uniqKey="Puneet P">P Puneet</name></author><author><name sortKey="Mcgrath, Ma" uniqKey="Mcgrath M">MA McGrath</name></author><author><name sortKey="Tay, Hk" uniqKey="Tay H">HK Tay</name></author><author><name sortKey="Al Riyami, L" uniqKey="Al Riyami L">L Al-Riyami</name></author><author><name sortKey="Rzepecka, J" uniqKey="Rzepecka J">J Rzepecka</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Kamalakannan, Vijayan" sort="Kamalakannan, Vijayan" uniqKey="Kamalakannan V" first="Vijayan" last="Kamalakannan">Vijayan Kamalakannan</name></noRegion><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name><name sortKey="Narayanan, Rangarajan Badri" sort="Narayanan, Rangarajan Badri" uniqKey="Narayanan R" first="Rangarajan Badri" last="Narayanan">Rangarajan Badri Narayanan</name><name sortKey="Shiny, Abijit" sort="Shiny, Abijit" uniqKey="Shiny A" first="Abijit" last="Shiny">Abijit Shiny</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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